Publications | Multifunkimlab

2025

Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology

Hrtonova V., Nejedly P., Travnicek V., Cimbalnik J., Matouskova B., Pail M., Peter-Derex L., Grova C., Gotman J., Halamek J., Jurak P., Brazdil M., Klimes P., Frauscher B.

Clinical Neurophysiology, 169: 33-46 (2025)

Dialogue mechanisms
between astrocytic and neuronal networks: a whole-brain modelling approach

Ali O.B.K., Vidal A., Grova C., Benali H.

PLoS computational biology, 21(1), e1012683 (2025)

Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy

Xie K., Sahlas E., Ngo A., Chen J., Arafat T., Royer J., Zhou Y., Rodríguez-Cruces R., Dascal A., Caldairou B. and Fadaie F., Barnett A., Audrain S., Larivière S., Caciagli L., Pana R., Weil A.G., Grova C., Frauscher B., Schrader D.V., Zhang Z., Concha L., Bernasconi A., Bernasconi N., Bernhardt B.C.

Nature Communications, 16(1), 10145 (2025)

NIRSTORM: a Brainstorm extension dedicated to functional Near Infrared Spectroscopy (fNIRS) data analysis, advanced 3D reconstructions, and optimal probe design

Delaire E., Vincent T., Cai Z., Machado A., Hugueville L., Schwartz D., Tadel F., Cassani R., Bherer L., Lina J.M., Pélégrini-Issac M., Grova C.

Neurophotonics, 12(2):025011 (2025)

The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies

Avigdor T., Ren G., Abdallah C., Dubeau F., Grova C., Frauscher B.

Advanced science, 12(19):e2409608 (2025)

Spectral and network investigation reveals distinct power
and connectivity patterns between phasic and tonic REM sleep

Avigdor T., Peter-Derex L., Ho A., Schiller K., Wang Y., Abdallah C., Delaire E., Jaber K., Travnicek V., Grova C., Frauscher B.

Sleep, 14;48(8):zsaf133 (2025)

Validating MEG estimated resting-state connectome with intracranial EEG

Afnan J., Cai Z., Lina J.M., Abdallah C., Pellegrino G., Arcara G., Khajehpour H., Frauscher B., Gotman J., Grova C.

Network Neuroscience, 20;9(1):421-446 (2025)

2024

EEG source imaging technique to investigate sleep oscillations for simultaneous EEG-fMRI

Uji M., Jegou A., Cross N., Pomares F., Perrault A., Nguyen A., Aydin Ü., Lee KJ., Abdallah C., Frauscher B., Lina J.M., Dang-Vu T.T., Grova C.

Available on bioRxiv (2024)

Systematic review of seizure-onset patterns in stereo-electroencephalography: Current state and future directions

Abdallah C., Mansilla D., Minato E., Grova C., Beniczky S., Frauscher B.

Clinical Neurophysiology, 163: 112-123 (2024)

Consistency of electrical source imaging in presurgical evaluation of epilepsy across different vigilance states

Avigdor T., Abdallah C., Afnan J., Cai Z., Rammal S., Grova C., Frauscher B.

Annals of Clinical and Translational Neurology, 11(2): 389-403 (2024)

EEG/MEG source imaging of deep brain activity within the Maximum Entropy on the Mean framework: simulations and validation in epilepsy

Afnan J., Cai Z., Lina J.M., Abdallah C., Avigdor T., Delaire E., Ros V., Hedrich T., von Ellenrieder N., Kobayashi E., Frauscher B., Gotman J., Grova C.

Human Brain Mapping, 45(10): e26720 (2024)

A spatial perturbation framework to validate implantation of the epileptogenic zone

Jaber K., Avigdor T., Mansilla D., Ho A., Thomas J., Abdallah C., Chabardes S., Hall J., Minotti L., Kahane P.,

Grova C., Gotman J., Frauscher B.

Nature Communications, 15(1): 5253 (2024)

2023

Validating MEG source imaging of resting state oscillatory patterns with an intracranial EEG atlas

Afnan J., von Ellenrieder N., Lina J.M., Pellegrino G., Arcara G., Cai Z., Hedrich T., Abdallah C., Khajehpour H., Frauscher B., Gotman J., Grova, C.

Neuroimage, 274: 120158 (2023)

Targeted density electrode placement achieves high concordance with traditional high-density EEG for electrical source imaging in epilepsy

Horrillo-Maysonnial A., Avigdor T., Abdallah C., Mansilla D., Thomas J., von Ellenrieder N., Royer J., Bernhardt B., Grova C., Gotman J., Frauscher B.

Clinical Neurophysiology, 23: S1388-2457 (2023)

Hierarchical Bayesian Modeling of the Relationship between Task Related Hemodynamic Responses and Cortical Excitability

Cai Z., Pellegrino G., Lina J.M., Benali H., Grova C.

Human Brain Mapping, 44(3):876-900 (2023)

Neurophysiology, Neuropsychology, and Epilepsy, in 2022: Hills We Have Climbed and Hills Ahead

Frauscher B., Bénar C.G., Engel J.J., Grova C., Jacobs J., Kahane P., Wiebe S., Zjilmans M., Dubeau F.

Epilepsy Behavior, 143: 109221 (2023)

2022

Hemodynamic Correlates of Fluctuations in Neuronal Excitability: A Simultaneous Paired Associative Stimulation (PAS) and functional Near Infra-Red Spectroscopy (fNIRS) Study

Cai Z., Pellegrino G., Spilkin A., Delaire E., Uji, M., Abdallah C., Lina J.M., Fecteau S., Grova C.

Neuroimage Report, 2 (3), 100099 (2022)

Clinical yield of electromagnetic source imaging and hemodynamic responses in epilepsy: validation with intracerebral data

Abdallah C., Hedrich T., Koupparis A., Afnan J., Hall J., Gotman J., Dubeau F., Frauscher B., Kobayashi E., Grova C.

Neurology, 98(24):e2499-e2511 (2022)

Diffuse optical reconstructions of NIRS data using Maximum Entropy on the Mean

Cai Z., Machado A., Chowdhury R.A., Spilkin A., Vincent T., Aydin U., Pellegrino G., Lina J.M., Grova C.

Scientific Report, 12(1):2316 (2022)

2021

Trait-like gradients of functional connectivity are robust to state-dependent changes following sleep deprivation

Cross B., Paquola C., Pomares F., Perrault A., Jegou A., Nguyen A., Aydin U., Bernhardt B., Grova C., Dang-Vu T.T.

Neuroimage, 226: 226:117547 (2021)

Data-driven beamforming techniques to attenuate ballistocardiogram (BCG) artefacts in EEG/fMRI without detecting cardiac pulses in ECG recordings

Uji M., Cross N., Pomares F., Perrault A., Jegou A., Nguyen A., Aydin Ü., Lina J.M., Dang-Vu T.T., Grova C.

Human Brain Mapping, 42(12):3993-4021 (2021)

Evaluation of a Personalized Functional Near Infra-Red Optical Tomography Workflow using Maximum Entropy on the Mean

Cai Z., Uji M., Aydin Ü., Pellegrino G., Spilkin A., Delaire E., Abdallah C., Lina J.M., Grova, C.

Human Brain Mapping, 42(15):4823-4843 (2021)

Deconvolution of hemodynamic responses along the cortical surface using personalized functional near infrared spectroscopy

Machado A., Cai Z., Vincent T., Pellegrino G., Lina J.M., Kobayashi E., Grova C.

Scientific Report, 11(1): 5964 (2021)

Altered functional integration of brain activity is a marker of impaired cognitive performance following sleep deprivation

Cross N., Pomares F., Nguyen A., Perrault A., Jegou A., Uji M., Lee K.J., Razavipour F., Ali O.B.K., Aydin U., Benali H., Grova C., Dang-Vu T.T.

PLoS Biology, 19(11): e3001232 (2021)

Best practices for fNIRS publications

Yücel MA., Lühmann AV., Scholkmann F., Gervain J., Dan I., Ayaz H., Boas D., Cooper RJ., Culver J., Elwell CE., Eggebrecht A., Franceschini MA., Grova C., Homae F., Lesage F., Obrig H., Tachtsidis I., Tak S., Tong Y., Torricelli A., Wabnitz H., Wolf M.

Neurophotonics, 8(1):012101 (2021)

How cerebral cortex protects itself from interictal spikes: the alpha/beta inhibition mechanism

Pellegrino G., Hedrich T., Sziklas V., Lina J.M., Grova C., Kobayashi E.

Human Brain Mapping, 42(11):3352--3365 (2021)

2016-2020

Effects of Independent Component Analysis on magnetoencephalography source localization in presurgical frontal lobe epilepsy patients

Pellegrino G., Xu M., Alkuwaiti A., Porras-Bettancourt M., Lina J.M., Grova C., Kobayashi E.

Frontiers in Neurology, section Epilepsy, 11: 479 (2020)

MEG resting state connectivity in epilepsy predicts surgical outcome at the single patient level

Aydin Ü., Pellegrino G., Ali O.B.K., Abdallah C., Dubeau F., Lina J.M., Kobayashi E., Grova C.

Journal of Neural Engineering, 17(3):035007 (2020)

Accuracy and spatial properties of distributed magnetic source imaging (dMSI) techniques in the investigation of focal epilepsy patients

Pellegrino G., Hedrich T., Aydin Ü., Porras-Bettancourt M., Lina J.M., Grova C., Kobayashi E.

Human Brain Mapping, 41(11): 3019-3033 (2020)

Fast oscillations>40Hz localize the epileptogenic zone: an electrical source imaging study using high-density electroencephalography

Avigdor T., Abdallah C., von Ellenrieder N., Rubino A., Lo Russo G., Bernhardt B., Nobili L., Grova C., Frauscher B.

Clinical Neurophysiology, 132(2): 568-580 (2020)

Differences in MEG and EEG power-law scaling explained by a coupling between spatial coherence and frequency: a simulation study

Bénar CG., Grova C., Jirsa V., Lina J.M.

Journal of Computational Neuroscience, 1-11 (2019)

Inferior Longitudinal Fasciculus' Role in Visual Processing and Language Comprehension: A Combined MEG-DTI Study

Shin J., Rowley J., Chowdhury R.A., Jolicoeur P., Klein D., Grova C., Rosa-Neto P., Kobayashi E.

Frontiers in Neuroscience, 13:875 (2019)

Cortical reactivations during sleep spindles following declarative learning

Jegou A., Schabus M., Gosseries O., Dahmen B., Albouy G., Desseilles M., Sterpenich V., Phillips C., Maquet M., Grova C., Dang-Vu T.T.

Neuroimage, 195: 104-112 (2019)

Automatic removal of structured physiological noise for resting state functional connectivity MRI analysis

Lee KJ., Khoo HM., Fourcade C., Gotman J., Grova C.

Magnetic Resonance in Medicine, 58: 97-107 (2019)

Clinical yield of MEG distributed source imaging in epilepsy

Pellegrino G., Hedrich T., Chowdhury R.A., Hall J.A., Dubeau F., Lina J.M., Kobayashi E., Grova C.

Human Brain Mapping, 39(1): 218-231 (2018)

Reproducibility of EEG-MEG fusion source analysis of interictal spikes

Chowdhury R.A., Pellegrino G., Aydin U., Lina J.M., Dubeau F., Kobayashi E., Grova C.

Human Brain Mapping, 39(2): 880-901 (2018)

Disruption, emergence and lateralization of brain network hubs in mesial temporal lobe epilepsy

Lee KJ., Khoo H.M., Lina J.M., Dubeau F., Gotman J., Grova C.

Neuroimage Clinical, 20: 71-84 (2018)

Optimal positioning of optodes on the scalp for personalized functional near-infrared spectroscopy investigations

Machado A., Cai Z., Pellegrino G., Marcotte O., Vincent T., Lina J.M., Kobayashi E., Grova, C.

Journal of Neurosciences - Methods, 309: 91-108 (2018)

The movement time analyser task investigated with functional near infrared spectroscopy: an ecologic approach for measuring hemodynamic response in the motor system

Vasta R., Cerasa A., Gramigna V., Augimeri A., Olivadese G., Pellegrino G., Martino I., Machado A., Cai Z., Caracciolo M., Grova C., Quattrone A.

Aging Clinical and Experimental Research, 29(2):311-318 (2017)

Zoomed MRI guided by combined EEG/MEG source analysis: A multimodal approach for optimizing presurgical epilepsy work-up

Aydin Ü., Rampp S., Wollbrink A., Kugel H., Cho J-H., Knösche, TR., Grova C., Wellmer J, Wolters CH.

Brain Topography, 30(4): 417-433 (2017)

Comparison of the spatial resolution of source imaging techniques in high-density EEG and MEG

Hedrich T., Pellegrino G., Kobayashi E., Lina J.M., Grova C.

Neuroimage, 157:531-544 (2017)

Validation of Shared and Specific Independent Component Analysis (SSICA) for between-group comparisons in fMRI

Maneshi M., Vahdat S., Gotman J., Grova C.

Frontiers in Neuroscience, section Brain Imaging Methods, 10:417 (2016)

Simulation and Validation in Brain Image Analysis

Tohka J., Bellec P., Grova C., Reilhac A.

Computational Intelligence and Neuroscience, 1041058. Special Issue Editorial (2016)

SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity

Lee KJ., Lina J.M., Gotman J., Grova C.

Neuroimage, 134:434-449 (2016)

Intracranial EEG (iEEG) potentials simulated from MEG sources: a new approach to correlate MEG and iEEG

Grova C., Aiguabella M., Zelmann R., Lina J.M., Hall J.A., Kobayashi E.

Human Brain Mapping, 37(5):1661-83 (2016)

Source localization of the seizure onset zone from ictal EEG/MEG data

Pellegrino G., Hedrich T., Chowdhury R.A., Hall J., Lina J.M., Dubeau F., Kobayashi E., Grova C.

Human Brain Mapping, 37(7):2528-46 (2016)

Hemodynamic response to Interictal Epileptiform Discharges addressed by personalized EEG-fNIRS recordings

Pellegrino G., Machado A., Von Ellenrieder N., Watanabe S., Lina J.M., Hall J., Kobayashi E., Grova C.

Frontiers in Neuroscience, section Brain Imaging Methods, 10:102 (2016)

Localization Accuracy of Distributed Inverse Solutions for Electric and Magnetic Source Imaging of Interictal Epileptic Discharges in Patients with Focal Epilepsy

Heers M., Chowdhury R.A., Hedrich T., Dubeau F., Hall J.A., Lina J.M., Grova C., Kobayashi E.

Brain Topography, 29(1):162-81 (2016)

Detection and magnetic source imaging of fast oscillations (40-160 Hz) recorded with magnetoencephalography

Von Ellenrieder N., Pellegrino G., Hedrich T., Gotman J., Lina J.M., Grova C., Kobayashi E.

Brain Topography, 29(2):218-31 (2016)

Complex patterns of spatially extended generators of epileptic activity: Comparison of source localization methods cMEM and 4-ExSo-MUSIC on High Resolution EEG and MEG data

Chowdhury R.A., Merlet I., Birot G., Kobayashi E., Nica A., Biraben A., Wendling F., Lina J.M., Albera L. Grova C.

Neuroimage, 143:175-195 (2016)

2011-2015

Multimodal Fusion of ElectroEncephalography (EEG) and MagnetoEncephalography (MEG) within the Maximum Entropy on the Mean Framework

Chowdhury R.A., Zerouali Y., Hedrich T., Heers M., Kobayashi E., Lina J.M., Grova C.

Brain Topography, 28(6):785-812 (2015)

Spatial correlation of hemodynamic changes related to interictal epileptic discharges with electric and magnetic source imaging

Heers M., Hedrich T., An D., Dubeau F., Gotman J., Grova C., Kobayashi E

Human Brain Mapping, 35(9):4396-414 (2014)

Detection of abnormal resting-state networks in individual patients suffering from focal epilepsy: an initial step toward individual connectivity assessment

Dansereau CL., Bellec P., Lee KJ., Pittau F., Gotman J., Grova C.

Frontiers in Neuroscience,8:419 (2014)

Specific Resting-state Brain Networks in Mesial Temporal Lobe Epilepsy

Maneshi M., Vahdat S., Fahoum F., Grova C., Gotman J.

Frontiers in Neurology, section Epilepsy, 5:127 (2014)

Optimal optode montage on EEG/fNIRS caps informed by multimodal functional information

Machado A., Marcotte O., Lina JM., Kobayashi E., Grova C.

Journal of Biomedical Optics, 19(2):026010 (2014)

Wavelet-based localization of oscillatory sources from MagnetoEncephaloGraphy data

Lina J.M., Chowdhury R.A., Lemay E., Kobayashi E., Grova C.

IEEE Transactions on Biomedical Engineering, 61(8):2350-64 (2014)

MEG Source Localization of spatially extended generators of epileptic activity: Comparing Entropic and Hierarchical Bayesian Approaches.

Chowdhury R.A., Lina J.M., Kobayashi E., Grova C.

PLoS ONE, 8(2):e55969 (2013)

Resting-State Connectivity of the Sustained Attention Network Correlates with Disease Duration in Idiopathic Generalized Epilepsy

Maneshi M., Moeller F., Gotman J., Grova C.

PLoS ONE, 7(12):e50359 (2012)

Shared and Specific Independent Components Analysis for Between-Groups Comparison

Vahdat S., Maneshi M., Grova C., Gotman J., Milner T.

Neural Computation, 24(11):3052-90 (2012)

Patterns of altered functional connectivity in mesial temporal lobe epilepsy

Pittau F., Grova C., Moeller F., Dubeau F., Gotman J.

Epilepsia, 53(6):1013-23 (2012)

Detection of hemodynamic responses to epileptic activity using simultaneous Electro-Encephalography (EEG) / Near Infra Red Spectroscopy (NIRS) acquisitions

Machado A., Lina J.M., Tremblay J., Lassonde M., Nguyen D.K., Lesage F., Grova C.

Neuroimage, 56(1):114-25 (2011)

Functional connectivity in patients with idiopathic generalized epilepsy

Moeller F., Maneshi M., Gholipour T., Pittau F., Bellec P., Dubeau F., Grova C., Gotman J.

Epilepsia, 52(3):515-22 (2011)

2006-2010

Structures Involved at the Time of Temporal Lobe Spikes Revealed by Inter-Individual Group Analysis of EEG/fMRI Data

Kobayashi E., Grova C., Tyvaert L., Dubeau F., Gotman J.

Epilepsia, 50(12):2549-56 (2009)

Clustering of atlas-defined cortical regions based on relaxation times and proton density

Aubert-Broche B., Grova C., Pike GB., Collins DL.

Neuroimage, 47(2):523-32 (2009)

Oscillatory activity in parietal and dorsolateral prefrontal cortex during retention in visual short-term memory: Additive effects of spatial attention and memory load

Grimault S., Robitaille N., Grova C., Lina J-M., Dubarry A.S., and Jolicœur P.

Human Brain Mapping, 30(10):3378-92 (2009)

Concordance between EEG source localization and simultaneous EEG/fMRI studies of epileptic spikes

Grova C., Daunizeau J., Kobayashi E., Bagshaw A.P., Lina J.M., Dubeau F., Gotman J.

Neuroimage, 39(2):755-74 (2008)

Effects of fluctuating physiological rhythms during prolonged EEG-fMRI studies

Tyvaert L., LeVan P., Grova C., Dubeau F., Gotman J.

Clinical Neurophysiology, 119(12):2762-74 (2008)

Non-invasive pre-surgical investigation of a 10 year-old epileptic boy using simultaneous EEG-NIRS

Gallagher A., Lassonde M., Bastien D., Vannasing P., Lesage F., Grova C., Bouthillier A., Carmant L., Lepore F., Béland R., Nguyen DK.

Seizure, 17(6):576-82 (2008)

Symmetrical Event-Related EEG/fMRI Information Fusion in a Variational Bayesian Framework

Daunizeau J., Grova C., Marrelec G., Mattout J., Jbabdi S., Pelegrini-Issac M, Lina J.M., Benali H.

Neuroimage, 36(1):69-87 (2007)

Negative BOLD responses to epileptic spikes

Kobayashi E., Bagshaw A.P., Grova C., Dubeau F., Gotman J.

Human Brain Mapping, 27(6):488-97 (2006)

Widespread and intense BOLD changes during brief focal electrographic seizures

Kobayashi E., Hawco C.S., Grova C., Dubeau F., Gotman J.

Neurology, 66(7):1049-55 (2006)

EEG-fMRI of Epileptic Spikes : Concordance with EEG Source Localization and Intracranial EEG

Bénar C.G., Grova C., Kobayashi E., Bagshaw A.P., Aghakhani Y., Dubeau F., Gotman J.

Neuroimage, 30(4):1161-70 (2006)

Anatomically informed interpolation of fMRI data on the cortical surface

Grova C., Makni S., Flandin G., Ciuciu P., Gotman J., Poline J.B.

Neuroimage, 31(4):1475-86 (2006)

Evaluation of EEG localization methods using realistic simulations of interictal spikes

Grova C., Daunizeau J., Lina J.M., Bénar C., Benali H. and Gotman J.

Neuroimage, 29(3):734-53 (2006)

Using voxel-specific hemodynamic response function in EEG-fMRI data analysis: an estimation and detection model

Lu Y., Grova C., Kobayashi E., Dubeau F. and Gotman J.

Neuroimage, 34(1):195-203, (2006)

Using Voxel-specific Hemodynamic Response Function in EEG-fMRI data analysis

Lu Y., Bagshaw A.P., Grova C., Kobayashi E., Dubeau F. and Gotman J.

Neuroimage, 32(1):238-247 (2006)

Model for defining and reporting reference-based validation protocol in medical image processing

Jannin P., Grova C., and Maurer Jr C.R.

International Journal of Computer Assisted Radiology and Surgery, 1(2):63-73 (2006)

Gray Matter Heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders?

Kobayashi E., Bagshaw A.P., Grova C., Gotman J., Dubeau F.

Brain, 129(Pt 2):366-74 (2006)

2000-2005

Statistical Maps for EEG Dipolar Source Localization

Bénar C.G., Gunn R.N., Grova C., Champagne B., Gotman J.

IEEE Transactions on Biomedical Engineering, 52(3) pp. 401-413 (2005)

Assessing the relevance of fMRI based-prior in the EEG inverse problem: a Bayesian model comparison approach.

Daunizeau J., Grova C., Mattout J. Marrelec G., Clonda D., Goulard B., Pélégrini-Isaac M., Lina J.M., Benali H.

IEEE Transactions on Signal Processing, special section on signal processing aspects of brain imaging, 53(9) pp. 3461-3472 (2005)

Generalized Epileptic Discharges: Thalamo-cortical Activation and Suspension of the Default State of the Brain

Gotman J., Grova C., Bagshaw A.P., Kobayashi E., Aghakhani Y., Dubeau F.

Proceedings of the National Academy of Sciences of the USA, 102(42) pp. 15236-15240 (2005)

PET-SORTEO: Validation and Development of Database of Simulated PET Volumes

Reilhac A., Batan G., Michel C., Grova C., Tohka J., Collins D.L., Costes N., Evans A.C.

IEEE Transactions on Nuclear Science, 52(5) pp. 1321-1328 (2005)

From anatomic standardization analysis of perfusion SPECT data to perfusion pattern modelling

Grova C., Jannin P., Buvat I., Benali H., Bansard J.Y., Biraben A. and Gibaud B.

Academic Radiology, invited paper, 12(5) pp. 554-565 (2005)

Detection of inter-hemispheric asymmetries of brain perfusion in SPECT

Aubert-Broche B., Grova C., Jannin P., Buvat I., Benali H., Gibaud B.

Physics in Medicine and Biology, 48 pp. 1505-1517 (2003)

A methodology for generating normal and pathological brain perfusion SPECT images for evaluation of MRI/SPECT fusion methods: application in epilepsy

Grova C., Jannin P., Biraben A., Buvat I., Benali H., Bernard A.-M., Scarabin J.-M., Gibaud B.

Physics in Medicine and Biology. 48 pp. 4023-4043 (2003)

Data fusion in medical imaging: methodological review based on clinical context

Jannin P., Grova C., and Gibaud B.

ITBM-RBM Innovation et technologie en biologie et médecine, 22(4) pp. 196-215 (2001)

A Data Fusion Environment for Multimodal and Multi-Informational Neuro-Navigation

Jannin P., Fleig O.J., Seigneuret E., Grova C., Morandi X., and Scarabin J.M.

Journal of Computer Aided Surgery, 5(1) pp. 1-10 (2000)